Kani Ali Hashemi, Alavian Seyed Moayed, Esmaillzadeh Ahmad, Adibi Peyman, Haghighatdoost Fahimeh, Azadbakht Leila
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Horm Metab Res. 2017 Sep;49(9):687-692. doi: 10.1055/s-0042-118707. Epub 2017 Jul 31.
Few studies have focused on the effects of a soy containing diet on inflammation and serum leptin level among patients with nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to determine the effects of such a diet in patients with NAFLD. Forty-five patients with NAFLD participated in this parallel randomized clinical trial for 8 weeks. Patients were randomly allocated to these 3 groups: 1) a low-calorie diet, 2) low-calorie low-carbohydrate diet, and 3) low-calorie low-carbohydrate soy containing diet. Low-calorie low-carbohydrate soy containing diet reduced fasting blood sugar (FBS) and serum insulin level significantly compared to other 2 groups (-11.6±2.8 vs. -6.3±1.7 and -3.1±1.0 mg/dl for FBS; and -5.1±1.2 vs. -1.2±0.3 and -1.7±0.5 mg/dl for serum insulin level). Serum hs-CRP level was also reduced significantly following low-calorie low-carbohydrate soy containing diet (-0.8±0.1 vs. -0.1±0.06 and -0.1±0.06 mg/dl). Both systolic and diastolic blood pressures were reduced significantly. Changes in leptin level tended to be different among 3 groups. After trial, 5 patients in each intervention group did not have NAFLD. From 6 patients in grade 2 at the beginning only 1 patient remained and others moved to grade 1. Low-calorie low-carbohydrate soy containing diet could reduce glycemic indices, hs CRP, systolic and diastolic blood pressure in a significant level in patients with NAFLD. However, these effects were dependent on baseline weight and further studies are needed to clarify the effect of such interventions in subjects with different BMI categories.
很少有研究关注含大豆饮食对非酒精性脂肪性肝病（NAFLD）患者炎症和血清瘦素水平的影响。因此，我们旨在确定这种饮食对NAFLD患者的影响。45例NAFLD患者参与了这项为期8周的平行随机临床试验。患者被随机分为3组：1）低热量饮食组，2）低热量低碳水化合物饮食组，3）低热量低碳水化合物含大豆饮食组。与其他两组相比，低热量低碳水化合物含大豆饮食组显著降低了空腹血糖（FBS）和血清胰岛素水平（FBS分别为-11.6±2.8 vs. -6.3±1.7和-3.1±1.0mg/dl；血清胰岛素水平分别为-5.1±1.2 vs. -1.2±0.3和-1.7±0.5mg/dl）。低热量低碳水化合物含大豆饮食后血清hs-CRP水平也显著降低（-0.8±0.1 vs. -0.1±0.06和-0.1±0.06mg/dl）。收缩压和舒张压均显著降低。3组之间瘦素水平的变化趋势有所不同。试验后，每个干预组有5例患者不再患有NAFLD。开始时6例2级患者中仅1例仍为2级，其他患者转为1级。低热量低碳水化合物含大豆饮食可显著降低NAFLD患者的血糖指数、hs-CRP、收缩压和舒张压。然而，这些效果取决于基线体重，需要进一步研究以阐明此类干预对不同BMI类别的受试者的影响。
