He Xianghua, Zhang Wei, Pang Guofang, Lv Yuan, Hu Caiyou, Yang Ze
Department of Neurology, Jiangbin Hospital, No 85 Hedi Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, China.
The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, No.1 Dahua Road, Dongdan, Beijing, 100730, People's Republic of China.
BMC Geriatr. 2017 Jul 31;17(1):169. doi: 10.1186/s12877-017-0536-y.
Metabolic syndrome (MetS) was a risk factor for cardiovascular diseases, yet the prevalence of MetS among nonagenarians and centenarians was rarely reported. Here we investigated the prevalence of MetS and its components among nonagenarians and centenarians in our Zhuang population from Bama, Guangxi Zhuang Autonomous Region, China.
In Bama area, there registered 881 individuals who lived more than 90 years old in 269,800 local residents and our study involved 307 long-lived participants and 486 local younger (35-68 years) persons, as controls. MetS was defined according to the revised National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATPIII) criteria.
The overall prevalence estimates of MetS among longevity group were 28.0% based on NCEP ATPIII criteria. The most common metabolic component was elevated blood pressure (61.1%), followed by raised fasting glucose (39.1%) and low high-density lipoprotein cholesterol (low HDL-C) (28.0%). The prevalence of MetS and abdominal obesity in women (33.6% and 22.1% respectively) was higher than that of men (19.8% and 3.7% respectively) (P < .001-0.019). Compared with controls, long-lived individuals were more likely to have two or more metabolic abnormalities (P < 0.001), and less likely to have zero or one metabolic abnormality (P < 0.001-0.020).
This study showed substantiality the prevalence and clinical profile of MetS in longevity population in Guangxi Zhuang Autonomous Region, China.
代谢综合征（MetS）是心血管疾病的一个危险因素，但关于九旬老人和百岁老人中MetS的患病率鲜有报道。在此，我们调查了中国广西壮族自治区巴马县壮族人群中九旬老人和百岁老人MetS及其组成成分的患病率。
在巴马地区，269,800名当地居民中登记有881名年龄超过90岁的个体，我们的研究纳入了307名长寿参与者和486名当地年轻（35 - 68岁）人群作为对照。MetS根据修订后的美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP ATPIII）标准进行定义。
根据NCEP ATPIII标准，长寿组中MetS的总体患病率估计为28.0%。最常见的代谢成分是血压升高（61.1%），其次是空腹血糖升高（39.1%）和高密度脂蛋白胆固醇降低（低HDL - C）（28.0%）。女性中MetS和腹型肥胖的患病率（分别为33.6%和22.1%）高于男性（分别为19.8%和3.7%）（P <.001 - 0.019）。与对照组相比，长寿个体更有可能有两种或更多种代谢异常（P < 0.001），而出现零种或一种代谢异常的可能性较小（P < 0.001 - 0.020）。
本研究充分显示了中国广西壮族自治区长寿人群中MetS的患病率及临床特征。
