Vázquez-Hernández Nallely, González-Tapia Diana C, Martínez-Torres Nestor I, González-Tapia David, González-Burgos Ignacio
Laboratorio de Psicobiología, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jal., Mexico.
Laboratorio de Psicobiología, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jal., Mexico; Centro Universitario del Norte, Universidad de Guadalajara, Colotlán, Jal., México.
Neurosci Lett. 2017 Sep 14;657:27-31. doi: 10.1016/j.neulet.2017.07.040. Epub 2017 Jul 29.
Rehabilitation is a process which favors recovery after brain damage involving motor systems, and neural plasticity is the only real resource the brain has for inducing neurobiological events in order to bring about re-adaptation. Rats were placed on a treadmill and made to walk, in different groups, at different velocities and with varying degrees of inclination. Plastic changes in the spines of the apical and basal dendrites of fifth-layer pyramidal neurons in the motor cortices of the rats were detected after study with the Golgi method. Numbers of dendritic spines increased in the three experimental groups, and thin, mushroom, stubby, wide, and branched spines increased or decreased in proportion depending on the motor demands made of each group. Along with the numerical increase of spines, the present findings provide evidence that dendritic spines' geometrical plasticity is involved in the differential performance of motor activity.
康复是一个有利于脑损伤后涉及运动系统恢复的过程，而神经可塑性是大脑诱导神经生物学事件以实现重新适应的唯一真正资源。将大鼠置于跑步机上，使其在不同组中以不同速度和不同倾斜度行走。用高尔基方法研究后，检测大鼠运动皮层第五层锥体神经元顶树突和基底树突棘的可塑性变化。三个实验组的树突棘数量增加，细、蘑菇、短粗、宽和分支的树突棘根据每组的运动需求成比例增加或减少。随着树突棘数量的增加，目前的研究结果提供了证据，表明树突棘的几何可塑性参与了运动活动的差异表现。
