Bradshaw E G, Harper N J, Pleuvry B J, Modla C Y
J Pharm Pharmacol. 1986 Aug;38(8):623-4. doi: 10.1111/j.2042-7158.1986.tb03095.x.
The sensitivities of two in-vitro preparations to neuromuscular blocking agents have been compared. The guinea-pig phrenic nerve diaphragm preparation proved to be more sensitive to vecuronium, atracurium and pancuronium than the equivalent preparation from the rat. Only tubocurarine had a similar potency on the preparations from both species. This would suggest that the guinea-pig diaphragm would be the most appropriate bioassay preparation if only small quantities of drug were available. Small differences in the cholinesterase content of the preparations was not thought to be a likely reason for the differences between the two preparations.
比较了两种体外制剂对神经肌肉阻滞剂的敏感性。结果表明，豚鼠膈神经膈肌制剂对维库溴铵、阿曲库铵和泮库溴铵的敏感性高于大鼠的同等制剂。只有筒箭毒碱对两种动物的制剂具有相似的效力。这表明，如果只有少量药物可用，豚鼠膈肌将是最合适的生物测定制剂。两种制剂胆碱酯酶含量的微小差异不太可能是造成它们之间差异的原因。
