Szikszay M, Snyder F R, London E D
J Pharm Pharmacol. 1986 Aug;38(8):625-7. doi: 10.1111/j.2042-7158.1986.tb03096.x.
The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer-344 rats. Morphine (4 mg kg-1) produced hypercapnia, hypoxia and slight acidosis, as compared with control values. Diltiazem (10 mg kg-1) alone did not affect these parameters; however, it significantly delayed the onset of the aforementioned effects of morphine.
在清醒的Fischer-344大鼠中评估了皮下注射吗啡和钙通道抑制剂地尔硫䓬对动脉血气和pH值的单独及联合作用。与对照值相比，吗啡（4毫克/千克）可导致高碳酸血症、低氧血症和轻度酸中毒。单独使用地尔硫䓬（10毫克/千克）不会影响这些参数；然而，它显著延迟了吗啡上述作用的起效时间。
