Szikszay M, Snyder F R, London E D
J Pharmacol Exp Ther. 1986 Jul;238(1):192-7.
Effects of s.c. doses of morphine and verapamil, alone and in combination, on arterial blood gases and pH, mean blood pressure and heart rate were assessed in partially restrained, awake Fischer-344 rats. As expected, morphine (4-16 mg/kg) produced a dose-dependent respiratory depression, as indicated by hypoxia, hypercapnia and acidosis. Verapamil, a calcium channel antagonist, alone (10 mg/kg) did not affect these parameters; however, it significantly attenuated and delayed the aforementioned effects of morphine. Morphine caused a slight increase in mean blood pressure, which was not dose dependent, whereas verapamil reduced blood pressure dramatically even in the presence of morphine. All groups showed some tachycardia, but rats treated with morphine alone showed the most pronounced increase in heart rate, which was antagonized by verapamil. The authors conclude that the interaction of verapamil with morphine's respiratory depressant effects differs from the previously reported potentiation of morphine's antinociceptive and hypothermic actions.
在部分受限的清醒Fischer-344大鼠中，评估了皮下注射剂量的吗啡和维拉帕米单独及联合使用对动脉血气、pH值、平均血压和心率的影响。正如预期的那样，吗啡（4-16毫克/千克）产生了剂量依赖性的呼吸抑制，表现为缺氧、高碳酸血症和酸中毒。钙通道拮抗剂维拉帕米单独使用（10毫克/千克）对这些参数没有影响；然而，它显著减弱并延迟了吗啡的上述作用。吗啡使平均血压略有升高，这与剂量无关，而维拉帕米即使在有吗啡的情况下也会显著降低血压。所有组均出现一定程度的心动过速，但单独使用吗啡治疗的大鼠心率增加最为明显，而维拉帕米可拮抗这种作用。作者得出结论，维拉帕米与吗啡呼吸抑制作用的相互作用不同于先前报道的对吗啡镇痛和体温过低作用的增强。
