Varun Babyamma Raghavan, Varghese Nettiyat Oommen, Sivakumar Trivandrum Thanappan, Joseph Anna Palliath
Department of Oral and Maxillofacial Pathology, PMS Institute of Dental Science and Research, Vattapara, Trivandrum, India.
Department of Conservative Dentistry, PMS Institute of Dental Science and Research, Vattapara, Trivandrum, India.
Iran J Med Sci. 2017 Jul;42(4):407-411.
Lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. Non-Hodgkin's lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extranodal sites, including the gastro intestinal tract, Waldeyer's ring, bone, skin, and brain. Intraoral non-Hodgkin's lymphoma is uncommon and may affect either the jaw bones or occur within the soft tissues of the oral cavity. Here we report a case of non-Hodgkin's lymphoma in a 65-year-old male patient who presented with a growth from the extraction socket. Non-Hodgkin's lymphoma presenting as a growth from the extraction socket is unusual. An orthopantamograph (OPG) was taken which revealed a diffuse radiolucent defect in relation to the extraction socket of the left lower molar region. Routine hemogram, urine analysis, and chest radiograph were normal. Incisional biopsy was performed and the tissue was subjected to histopathological examination. Histopathological and immunohistochemical analysis confirmed the diagnosis of B-cell lymphoma. The patient was referred to a regional cancer institute for further management, where chemotherapy was planned. However, prior to chemotherapy, the patient was diagnosed with brain metastasis and he expired in hospital within one month.
淋巴瘤是具有广泛临床和病理特征的实体恶性肿瘤。非霍奇金淋巴瘤（NHL）是淋巴瘤的一种亚型，三分之二的病例表现为淋巴结肿大。据报道，其余三分之一的NHL病例发生在结外部位，包括胃肠道、咽淋巴环、骨骼、皮肤和脑。口腔内非霍奇金淋巴瘤并不常见，可累及颌骨或发生在口腔软组织内。在此，我们报告一例65岁男性患者的非霍奇金淋巴瘤，该患者表现为拔牙窝处肿物。以拔牙窝处肿物形式出现的非霍奇金淋巴瘤并不常见。拍摄了曲面体层片（OPG），显示左下磨牙区拔牙窝处有弥漫性透射性缺损。血常规、尿液分析和胸部X线检查均正常。进行了切开活检，并对组织进行了组织病理学检查。组织病理学和免疫组织化学分析确诊为B细胞淋巴瘤。该患者被转诊至地区癌症研究所进行进一步治疗，计划进行化疗。然而，在化疗前，患者被诊断出脑转移，并在一个月内于医院死亡。
