Fabri P J, Gower W R, Weber C, Tuttle S
J Surg Res. 1986 Sep;41(3):333-7. doi: 10.1016/0022-4804(86)90045-4.
To determine if gastrin in hyperparathyroid glands is true gastrin or artifact and to determine the frequency of gastrin in parathyroid glands, 20 parathyroid glands from 11 patients with hyperparathyroidism but without MEA were extracted and analyzed for gastrin. The parathyroid glands from 4 out of 11 patients had measurable gastrin immunoreactivity (10.7 + 6 pg/mg tissue). Column separation chromatography confirmed that this was true gastrin (40% G-34; 50% G-17). Immunohistochemistry with ABC (avidin biotin complex) immunoperoxidase confirmed the presence of gastrin in cytoplasmic vesicles in scattered parathyroid cells. True gastrin does exist in some cells in some patients with hyperparathyroidism.
为了确定甲状旁腺中的胃泌素是真正的胃泌素还是人为产物，并确定甲状旁腺中胃泌素的出现频率，从11例甲状旁腺功能亢进但无多发性内分泌腺瘤（MEA）的患者中提取了20个甲状旁腺，并对其进行胃泌素分析。11例患者中有4例的甲状旁腺具有可测量的胃泌素免疫反应性（10.7±6 pg/mg组织）。柱分离色谱法证实这是真正的胃泌素（40%的G-34；50%的G-17）。采用抗生物素蛋白-生物素复合物（ABC）免疫过氧化物酶进行免疫组织化学分析，证实散在的甲状旁腺细胞的细胞质小泡中存在胃泌素。在一些甲状旁腺功能亢进患者的某些细胞中确实存在真正的胃泌素。
