Layoun Michael E, Aboulhosn Jamil A, Tobis Jonathan M
Tex Heart Inst J. 2017 Jun 1;44(3):189-197. doi: 10.14503/THIJ-16-6027. eCollection 2017 Jun.
Patent foramen ovale has been associated with multiple pulmonary diseases, such as pulmonary hypertension, platypnea-orthodeoxia syndrome, and chronic obstructive pulmonary disease. A connection between patent foramen ovale and chronic pulmonary disease was first described more than 2 decades ago in case reports associating patent foramen ovale with more severe hypoxemia than that expected based on the severity of the primary pulmonary disease. It has been suggested that patients with both chronic pulmonary disease and patent foramen ovale are subject to severe hypoxemia because of the right-to-left shunt. Furthermore, investigators have reported improved systemic oxygenation after patent foramen ovale closure in some patients with chronic pulmonary disease. This review focuses on the association between chronic pulmonary disease and patent foramen ovale and on the dynamics of a right-to-left shunt, and it considers the potential benefit of patent foramen ovale closure in patients who have hypoxemia that is excessive in relation to the degree of their pulmonary disease.
卵圆孔未闭与多种肺部疾病相关，如肺动脉高压、平卧呼吸-直立性低氧血症综合征和慢性阻塞性肺疾病。卵圆孔未闭与慢性肺部疾病之间的联系最早在20多年前的病例报告中被描述，这些报告将卵圆孔未闭与比基于原发性肺部疾病严重程度预期更严重的低氧血症相关联。有人提出，患有慢性肺部疾病和卵圆孔未闭的患者由于右向左分流而容易出现严重低氧血症。此外，研究人员报告称，一些慢性肺部疾病患者在卵圆孔未闭封堵术后全身氧合得到改善。本综述重点关注慢性肺部疾病与卵圆孔未闭之间的关联以及右向左分流的动态变化，并考虑卵圆孔未闭封堵术对那些低氧血症程度相对于其肺部疾病程度过高的患者的潜在益处。
