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脊髓原发性多形性黄色星形细胞瘤:一例报告并文献复习

Primary pleomorphic xanthoastrocytoma of the spinal cord: A case report and review of literature.

作者信息

Sharma Mayur, Velho Vernon, Binayake Rachana, Kharosekar Hrushikesh

机构信息

Department of Neurosurgery, Grant Medical College and Sir J.J. Group of Hospitals, Byculla, Mumbai, Maharashtra, India.

Department of Neuropathology, Grant Medical College and Sir J.J. Group of Hospitals, Byculla, Mumbai, Maharashtra, India.

出版信息

Asian J Neurosurg. 2017 Jul-Sep;12(3):566-569. doi: 10.4103/1793-5482.145547.

Abstract

Primary pleomorphic xanthoastrocytoma (PXA) of the spinal cord is a rare slow growing tumor. To our knowledge, only five such cases have been reported in the literature till date. We report the clinical, radiological, and histopathological features of a spinal PXA in a 23-year-old female previously operated 5 years back for a spinal tumor, presented with weakness in lower limbs, sphincter incontinence and low back pain. Magnetic resonance imaging scan with contrast reveals an intramedullary lesion in the spinal cord from D8-D10 level. The patient was operated with reexploration of the previous incision, and gross total excision was achieved. Histopathology confirmed the diagnosis of PXA. Clinical and radiological follow-up is required to detect early recurrence. Adjunct radiotherapy or and chemotherapy should be considered only when there is postoperative residual or recurrence, however there are no definite guidelines in view of the rarity of this condition.

摘要

脊髓原发性多形性黄色星形细胞瘤(PXA)是一种罕见的生长缓慢的肿瘤。据我们所知,迄今为止文献中仅报道过5例此类病例。我们报告了一名23岁女性脊髓PXA的临床、放射学和组织病理学特征,该女性5年前曾因脊髓肿瘤接受手术,此次出现下肢无力、括约肌失禁和腰痛。增强磁共振成像扫描显示脊髓D8 - D10节段有髓内病变。患者接受手术,重新切开原切口,实现了肿瘤全切。组织病理学确诊为PXA。需要进行临床和放射学随访以早期发现复发。仅在术后有残留或复发时才应考虑辅助放疗或化疗,然而鉴于这种疾病的罕见性,目前尚无明确的指导原则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3929/5532952/3e45990a1d67/AJNS-12-566-g002.jpg

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