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[抗结核药物继发的药物超敏反应伴嗜酸性粒细胞增多和全身症状综合征：病例报告]

[DRESS syndrome secondary to antituberculosis drugs: about a case].

作者信息

Jridi Siham, Azzeddine Rajae, Bourkadi Jamal Eddine

机构信息

Service de Pneumologie, Laboratoire PCIM, UCAM, Hôpital Arrazi, CHU Mohamed VI, Marrakech, Maroc.

Service de Pneumologie, Hôpital Moulay Youssef, CHU, Rabat, Maroc.

出版信息

Pan Afr Med J. 2017 May 11;27:37. doi: 10.11604/pamj.2017.27.37.11663. eCollection 2017.

DOI:10.11604/pamj.2017.27.37.11663
PMID:28761613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5516659/
Abstract

Drug hypersensitivity syndrome or Drug Rash with Eosinophilia and Systemic Symptoms or DRESS syndrome is a severe and potentially life-threatening toxidermia. It should be suspected in patients developing cutaneous reaction following drug intake. We report the case of a 45-year old patient treated for pulmonary tuberculosis (TPM+) who developed DRESS syndrom induced by antibacillaries.

摘要

药物超敏反应综合征或伴有嗜酸性粒细胞增多和全身症状的药疹或DRESS综合征是一种严重且可能危及生命的中毒性皮肤病。在服药后出现皮肤反应的患者中应怀疑此病。我们报告一例45岁接受抗结核治疗（服用吡嗪酰胺）的患者，其发生了由抗结核药物引起的DRESS综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/8c1e6cf2d012/PAMJ-27-37-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/2b1d4fc7a369/PAMJ-27-37-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/c7665a504b89/PAMJ-27-37-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/8c1e6cf2d012/PAMJ-27-37-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/2b1d4fc7a369/PAMJ-27-37-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/c7665a504b89/PAMJ-27-37-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba9/5516659/8c1e6cf2d012/PAMJ-27-37-g003.jpg

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本文引用的文献

1
[The "DRESS" syndrome in antituberculosis drugs].[抗结核药物所致的“药物超敏反应伴嗜酸性粒细胞增多和全身症状”综合征]
Rev Pneumol Clin. 2014 Jun;70(3):185-8. doi: 10.1016/j.pneumo.2013.10.004. Epub 2014 Mar 16.
2
The DRESS syndrome: a literature review.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：文献综述。
Am J Med. 2011 Jul;124(7):588-97. doi: 10.1016/j.amjmed.2011.01.017. Epub 2011 May 17.
3
[Management of drug reaction with eosinophilia and systemic symptoms (DRESS)].嗜酸性粒细胞增多和全身症状的药物反应（DRESS）的管理
Ann Dermatol Venereol. 2010 Nov;137(11):703-8. doi: 10.1016/j.annder.2010.04.024. Epub 2010 Aug 5.
4
The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations.基于典型的临床特征和病毒再激活，DRESS综合征的诊断已得到充分确立。
Br J Dermatol. 2007 May;156(5):1083-4. doi: 10.1111/j.1365-2133.2007.07807.x. Epub 2007 Mar 23.
5
Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?伴有全身症状的药物皮肤副作用临床模式的变异性：药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征真的存在吗？
Br J Dermatol. 2007 Mar;156(3):609-11. doi: 10.1111/j.1365-2133.2006.07704.x.
6
Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS).药物性假性淋巴瘤和药物超敏反应综合征（药物疹伴嗜酸性粒细胞增多和全身症状：DRESS）。
Semin Cutan Med Surg. 1996 Dec;15(4):250-7. doi: 10.1016/s1085-5629(96)80038-1.