Rezaei Omidvar, Pakdaman Hossein, Gharehgozli Kurosh, Simani Leila, Vahedian-Azimi Amir, Asaadi Sina, Sahraei Zahra, Hajiesmaeili Mohammadreza
Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Neurol. 2017 Apr 4;16(2):83-89.
After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neurocritical care domain, an electronic literature search was carried among articles published in English prior to March 2017. They were retrieved from PubMed, Scopus, EMBSCO, CINAHL, ISC and the Cochrane Library using keywords including "brain", "neurobiochemical marker", "neurocritical care", and "S100B protein". The integrative review included 48 studies until March 2017. S100B protein can be considered as a marker for blood brain barrier damage. The marker has an important role in the development and recovery of normal central nervous system (CNS) after injury. In addition to extra cerebral sources of S100B, the marker is principally built in the astroglial and Schwann cells. The neurobiochemical marker, S100B, has a pathognomonic role in the diagnosis of a broad spectrum of brain damage including traumatic brain injury (TBI), brain tumor, and stroke. Moreover, a potential predicting role for the neurobiochemical marker has been presumed in the efficiency of brain damage treatment and prognosis. However further animal and human studies are required before widespread routine clinical introduction of S100 protein.
脑损伤后，血清和脑脊液（CSF）中一些脑标志物（如S100B蛋白）的浓度与脑损伤的严重程度和预后相关。为了对S100B在人类神经重症监护领域的作用进行最新综述，我们在2017年3月之前发表的英文文章中进行了电子文献检索。使用包括“脑”、“神经生化标志物”、“神经重症监护”和“S100B蛋白”等关键词，从PubMed、Scopus、EMBSCO、CINAHL、ISC和Cochrane图书馆中检索文献。截至2017年3月，综合综述纳入了48项研究。S100B蛋白可被视为血脑屏障损伤的标志物。该标志物在损伤后正常中枢神经系统（CNS）的发育和恢复中起重要作用。除了S100B的脑外来源，该标志物主要存在于星形胶质细胞和雪旺细胞中。神经生化标志物S100B在诊断包括创伤性脑损伤（TBI）、脑肿瘤和中风在内的广泛脑损伤中具有特征性作用。此外，该神经生化标志物在脑损伤治疗效果和预后方面具有潜在的预测作用。然而，在S100蛋白广泛常规临床应用之前，还需要进一步的动物和人体研究。
