Karikios Deme John, Mileshkin Linda, Martin Andrew, Ferraro Danielle, Stockler Martin R
NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.
Peter MacCallum Cancer Centre, Melbourne, Australia.
ESMO Open. 2017 Jun 21;2(2):e000170. doi: 10.1136/esmoopen-2017-000170. eCollection 2017.
Australia has a publicly funded universal healthcare system which heavily subsidises the cost of most registered anticancer drugs. The use of anticancer drugs that are unfunded, that is, not subsidised by the government, entails substantial out-of-pocket costs for patients. We sought to determine how frequently Australian medical oncologists discuss and prescribe unfunded anticancer drugs, and their attitudes and beliefs about their use.
Members of the Medical Oncology Group of Australia (MOGA) completed an online survey about their clinical practices over a recent 3-month period. A negative binomial regression model was used to examine the influence of respondent characteristics on the rate of discussions about, and prescription of, unfunded anticancer drugs.
Of the 154 respondents (27% of 575 MOGA members), 92% had discussed and 68% had prescribed at least one unfunded anticancer drug in the last 3 months. Respondents reported discussing unfunded anticancer drugs with an average of 2.5 patients per month (95% CI 2.1 to 2.9), and prescribed them to an average of 0.9 patients per month (95% CI 0.7 to 1.2). The rate of discussing unfunded anticancer drugs was associated with being fully qualified (p=0.01), and being in a metropolitan practice (p=0.009), the rate of prescription was associated only with being in metropolitan practice (p=0.006). The concerns about discussing and prescribing unfunded anticancer drugs rated most important were as follows: 'potential to cause financial hardship' and 'difficulty for patients to evaluate the benefits versus the costs'.
Australian medical oncologists frequently discuss and prescribe unfunded anticancer drugs, and are concerned about their patients having to face difficult decisions and financial hardship. Further research is needed to better understand the factors that affect how oncologists and patients value expensive, unfunded anticancer drugs.
澳大利亚拥有一个由公共资金支持的全民医疗保健系统,该系统对大多数注册抗癌药物的费用给予高额补贴。使用无资金支持的抗癌药物,即未得到政府补贴的药物,会使患者承担大量自付费用。我们试图确定澳大利亚肿瘤内科医生讨论和开出处方使用无资金支持的抗癌药物的频率,以及他们对这些药物使用的态度和看法。
澳大利亚肿瘤内科医生小组(MOGA)的成员完成了一项关于他们在最近3个月临床实践的在线调查。使用负二项回归模型来检验受访者特征对讨论和开出处方使用无资金支持的抗癌药物频率的影响。
在154名受访者(占575名MOGA成员的27%)中,92%的人在过去3个月里讨论过至少一种无资金支持的抗癌药物,68%的人开出处方使用过至少一种此类药物。受访者报告称,每月平均与2.5名患者讨论无资金支持的抗癌药物(95%置信区间为2.1至2.9),每月平均为0.9名患者开出处方使用此类药物(95%置信区间为0.7至1.2)。讨论无资金支持的抗癌药物的频率与具备完全资质(p = 0.01)以及在大都市地区执业有关(p = 0.009),开出处方的频率仅与在大都市地区执业有关(p = 0.006)。对于讨论和开出处方使用无资金支持的抗癌药物,被认为最重要的担忧如下:“可能导致经济困难 ”以及 “患者难以评估收益与成本”。
澳大利亚肿瘤内科医生经常讨论和开出处方使用无资金支持的抗癌药物,并担心他们的患者不得不面对艰难的决策和经济困难。需要进一步开展研究,以更好地了解影响肿瘤内科医生和患者如何评估昂贵的、无资金支持的抗癌药物的因素。