内镜支架置入作为左侧恶性大肠梗阻手术的桥梁与急诊切除的比较:一项更新的荟萃分析。
Endoscopic Stenting as Bridge to Surgery versus Emergency Resection for Left-Sided Malignant Colorectal Obstruction: An Updated Meta-Analysis.
作者信息
Allievi Niccolò, Ceresoli Marco, Fugazzola Paola, Montori Giulia, Coccolini Federico, Ansaloni Luca
机构信息
1st Surgical Department, Papa Giovanni XXIII Hospital, Bergamo, Italy.
出版信息
Int J Surg Oncol. 2017;2017:2863272. doi: 10.1155/2017/2863272. Epub 2017 Jul 5.
INTRODUCTION
Emergency resection represents the traditional treatment for left-sided malignant obstruction. However, the placement of self-expanding metallic stents and delayed surgery has been proposed as an alternative approach. The aim of the current meta-analysis was to review the available evidence, with particular interest for the short-term outcomes, including a recent multicentre RCT.
METHODS
We considered randomized controlled trials comparing stenting as a bridge to surgery and emergency surgery for the management of left-sided malignant large bowel obstruction, performing a systematic review in MEDLINE, PubMed database, and the Cochrane libraries.
RESULTS
We initially identified a total of 2543 studies. After the elimination of duplicates and the screening of titles and abstracts, seven studies, for a total of 448 patients, were considered. The current meta-analysis revealed no difference in the mortality rate between the stent group and the emergency surgery group; the postoperative complication rate (37.84% versus 54.87%, = 0.02), the stoma rate (28.8% versus 46.02%, < 0.0001), and the incidence of wound infection (8.11% versus 15.49%, = 0.01) were reduced after stent as a bridge to surgery.
CONCLUSION
Colonic stenting as a bridge to surgery appears to be a safe approach to malignant large bowel obstruction. Possible advantages of this treatment can be identified in a reduced incidence of postoperative complications and a lower stoma rate. Further RCTs considering long-term outcomes and cost-effectiveness analysis are needed.
引言
急诊切除是左侧恶性梗阻的传统治疗方法。然而,有人提出放置自膨式金属支架并延迟手术作为一种替代方法。本荟萃分析的目的是回顾现有证据,特别关注短期结局,包括一项近期的多中心随机对照试验。
方法
我们纳入了比较支架置入作为手术桥梁与急诊手术治疗左侧恶性大肠梗阻的随机对照试验,并在MEDLINE、PubMed数据库和Cochrane图书馆进行了系统评价。
结果
我们最初共识别出2543项研究。在剔除重复项并筛选标题和摘要后,纳入了7项研究,共448例患者。当前的荟萃分析显示,支架组和急诊手术组的死亡率无差异;作为手术桥梁的支架置入术后,术后并发症发生率(37.84%对54.87%,P = 0.02)、造口率(28.8%对46.02%,P < 0.0001)和伤口感染发生率(8.11%对15.49%,P = 0.01)均有所降低。
结论
结肠支架置入作为手术桥梁似乎是治疗恶性大肠梗阻的一种安全方法。这种治疗方法的潜在优势在于术后并发症发生率降低和造口率较低。需要进一步开展考虑长期结局和成本效益分析的随机对照试验。
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