对于急性肿瘤性左侧结肠梗阻,作为手术桥梁的转流术、切除术或支架置入术:有治愈意向的研究的系统评价和网络荟萃分析。
Diversion, resection, or stenting as a bridge to surgery for acute neoplastic left-sided colonic obstruction: a systematic review and network meta-analysis of studies with curative intent.
机构信息
Imperial College Healthcare NHS Trust, London, UK.
University Hospital Henri Mondor (AP-HP), Créteil, France.
出版信息
Ann R Coll Surg Engl. 2021 Apr;103(4):235-244. doi: 10.1308/rcsann.2020.7137. Epub 2021 Mar 8.
INTRODUCTION
The debate on the best surgical management strategy for acute malignant left-sided colonic obstruction is ongoing. Decompressing colostomy (DC) and stenting as a bridge to surgery (SBTS) are the currently proposed alternative approaches to emergency colectomy (EC). However, the results of a traditional meta-analysis were inconclusive. Therefore, a network meta-analysis (NMA) was conducted to compare the three approaches for acute left-sided colonic obstruction.
METHODS
A systematic literature search of Embase, PubMed, Google Scholar and the Cochrane library was performed. A traditional meta-analysis and subsequent NMA were conducted.
FINDINGS
A significantly greater number of primary anastomoses were performed in the DC cohort than in the EC and SBTS cohorts. The 90-day mortality rate was significantly lower in the DC cohort than in the EC and SBTS cohorts. Higher costs were associated with the SBTS cohort (by US$2,000) than with the EC cohort. The locoregional recurrence rate was higher for the SBTS cohort than for the EC cohort.
CONCLUSIONS
Evidence from the first NMA suggests there may be some clinical advantages associated with DC as an alternative approach to the EC and SBTS approaches for adequately selected patients with malignant large bowel obstruction.
简介
对于急性恶性左侧结肠梗阻的最佳手术治疗策略仍存在争议。结肠造口减压术(DC)和支架作为手术桥接(SBTS)是目前提出的替代急诊结肠切除术(EC)的方法。然而,传统荟萃分析的结果尚无定论。因此,进行了网络荟萃分析(NMA)以比较三种治疗急性左侧结肠梗阻的方法。
方法
对 Embase、PubMed、Google Scholar 和 Cochrane 图书馆进行了系统的文献检索。进行了传统的荟萃分析和随后的 NMA。
结果
与 EC 和 SBTS 组相比,DC 组行一期吻合术的比例明显更高。DC 组的 90 天死亡率明显低于 EC 和 SBTS 组。SBTS 组的成本(2000 美元)高于 EC 组。与 EC 组相比,SBTS 组的局部复发率更高。
结论
来自首次 NMA 的证据表明,对于适当选择的恶性大肠梗阻患者,DC 作为 EC 和 SBTS 方法的替代方法可能具有一些临床优势。