Schmoyer Christopher, Mishra Suraj, Fulco Frank
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Department of Internal Medicine, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.
Case Reports Hepatol. 2017;2017:9312481. doi: 10.1155/2017/9312481. Epub 2017 Jul 6.
Calcineurin inhibitors remain an integral component of immunosuppressive therapy regimens following solid organ transplantation. Although nephrotoxicity associated with these agents is well documented, type IV renal tubular acidosis is a rare and potentially underreported complication following liver transplantation. Hepatologists must be able to recognize this adverse effect as it can lead to fatal hyperkalemia. We describe a case of tacrolimus-induced hyperkalemic type IV renal tubular acidosis in a patient following an orthotopic liver transplant for alcoholic cirrhosis.
钙调神经磷酸酶抑制剂仍然是实体器官移植后免疫抑制治疗方案的一个重要组成部分。尽管与这些药物相关的肾毒性已有充分记录，但IV型肾小管酸中毒是肝移植后一种罕见且可能未被充分报道的并发症。肝病学家必须能够识别这种不良反应，因为它可能导致致命的高钾血症。我们描述了一例在酒精性肝硬化原位肝移植术后患者中由他克莫司引起的高钾性IV型肾小管酸中毒病例。
