Huang T R, Li W, Peng B
Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12860. Epub 2017 Aug 1.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common clinical syndrome, and the mechanisms underlying the relationship between CP/CPPS and ED are still unclear. This study aimed to investigate the differential expression of 40 inflammatory mediators in patients with CP/CPPS and to demonstrate whether these mediators related to the severity of erectile function. Eighty cases of patients with CP/CPPS were selected, including 40 cases of IIIA and 40 cases of IIIB, with 20 cases of healthy men as controls. After collecting their expressed prostatic secretion, cytokines levels in EPS were determined by ELISA using ELISA kits. The IIEF-5 questionnaire was used to evaluate erectile function. IIEF-5 scores were significantly lower in the IIIA and IIIB groups than those in the control group. The expression of IL-8, IL-1β and ICAM-1 was markedly higher in the IIIA and IIIB groups than in the control group. The expression of IL-8, IL-1β and ICAM-1 in the IIIA group was higher than that in the IIIB group. The expression of IL-8, IL-1β and ICAM-1 was negatively correlated with IIEF-5 scores in both IIIA and IIIB patients. In conclusion, IL-8, IL-1β and ICAM-1 are possible indicators for the clinical diagnosis of CP/CPPS and evaluation of erectile function on patients with CP/CPPS.
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是一种常见的临床综合征，CP/CPPS与勃起功能障碍（ED）之间关系的潜在机制仍不清楚。本研究旨在调查CP/CPPS患者中40种炎症介质的差异表达，并证明这些介质是否与勃起功能的严重程度相关。选取80例CP/CPPS患者，其中IIIA型40例，IIIB型40例，另选20例健康男性作为对照。收集他们的前列腺分泌物后，使用ELISA试剂盒通过ELISA法测定EPS中的细胞因子水平。采用IIEF-5问卷评估勃起功能。IIIA组和IIIB组的IIEF-5评分显著低于对照组。IIIA组和IIIB组中IL-8、IL-1β和ICAM-1的表达明显高于对照组。IIIA组中IL-8、IL-1β和ICAM-1的表达高于IIIB组。IIIA组和IIIB组患者中IL-8、IL-1β和ICAM-1的表达与IIEF-5评分呈负相关。总之，IL-8、IL-1β和ICAM-1可能是CP/CPPS临床诊断及评估CP/CPPS患者勃起功能的指标。
