Department of Oncology, University of Oxford, Oxford, UK.
Wiley Interdiscip Rev RNA. 2018 Jan;9(1). doi: 10.1002/wrna.1432. Epub 2017 Aug 1.
RNA-binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post-transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP-centric approach, we explore the current knowledge surrounding contributers to post-transcriptional gene regulation (PTGR) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network. This network regulates survival and chemotherapy resistance in the contemporary context of the cancer cell. There is emerging evidence that cancers become dependent on PTGR factors for their survival. Further understanding of this network may identify innovative therapeutic targets as well as yield crucial insights into the hard-wiring of many malignancies, including ovarian cancer. WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Translation > Translation Mechanisms RNA in Disease and Development > RNA in Disease.
RNA 结合蛋白（RBPs）和非编码（nc）RNAs（如 microRNAs、长 ncRNAs 等）在转录后网络中合作，共同调节基因的表达，这些基因对于癌症行为的许多方面都很重要，包括对化疗的敏感性。在这里，我们采用以 RBP 为中心的方法，探索了当前关于卵巢癌中转录后基因调控（PTGR）贡献者的知识，并确定了一些共同点，这些共同点暗示存在一个进化上保守的核心 PTGR 网络。该网络在当代癌细胞的背景下调节生存和化疗耐药性。有新的证据表明，癌症的生存依赖于 PTGR 因子。进一步了解这个网络可能会确定创新的治疗靶点，并为许多恶性肿瘤（包括卵巢癌）的固有机制提供关键的见解。WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 本文属于以下类别： RNA 与蛋白质和其他分子的相互作用 > 蛋白质-RNA 相互作用：功能意义 翻译 > 翻译机制 RNA 在疾病与发育中的作用 > RNA 在疾病中的作用
