Ardakani Nima Mesbah, Tiwari Shevya M, Wood Benjamin A
*Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; and ‡Department of Dermatology, Charles Gairdner Hospital, Perth, Australia.
Am J Dermatopathol. 2017 Nov;39(11):853-856. doi: 10.1097/DAD.0000000000000886.
In this report, we present a novel case of pseudomelanoma, similar to that seen in a recurrent/traumatized nevus, in pre-existing nevi in a 36-year-old man a few months after recovering from an episode of severe Stevens-Johnson syndrome. The mechanism responsible for the atypical transformation of these nevi is likely the release of cytokines and growth factors in the microenvironment during the repair/regeneration process. It is important to be aware of this phenomenon, and specific inquiry about potential recent blistering skin disorder in addition to the other causes of trauma should be made when dealing with cases of pseudomelanoma to avoid misdiagnosis.
在本报告中，我们介绍了一例36岁男性在严重史蒂文斯-约翰逊综合征发作恢复数月后，其原有痣出现类似复发性/创伤性痣所见的假黑色素瘤新病例。这些痣发生非典型转变的机制可能是修复/再生过程中微环境中细胞因子和生长因子的释放。认识到这一现象很重要，在处理假黑色素瘤病例时，除了询问其他创伤原因外，还应特别询问近期是否有潜在的水疱性皮肤病，以避免误诊。
