Section of Dermatology, University of Chicago, Chicago, Illinois 60637, USA.
Arch Pathol Lab Med. 2011 Jul;135(7):842-6. doi: 10.5858/2010-0429-RAR.1.
The diagnosis of recurrent nevus poses a potential challenge to practicing pathologists. Although most recurrent nevi show uniform microscopic findings and pose no great diagnostic difficulty, a few cases exhibit some histopathologic features similar to, and in some cases indistinguishable from, melanoma. Historically, the term pseudomelanoma has been used in the literature to describe such recurrent nevi, although this label has the potential for confusion and is no longer the favored term for recurrent pigmented melanocytic nevi.
To describe historical, histopathologic, and immunohistochemical features of recurrent pigmented melanocytic nevi and to review briefly the literature surrounding the mechanism of recurrence.
Published peer-reviewed literature and the authors' personal experience.
Recognition of the histopathologic pattern of recurrent nevi leads the pathologist to the correct diagnosis in most cases; however, in particularly challenging specimens or in circumstances in which there is insufficient clinical history, immunohistochemical studies have proved helpful in distinguishing recurrent nevi from melanoma.
复发性痣的诊断对临床病理医生来说是一个潜在的挑战。虽然大多数复发性痣具有均匀的微观表现，诊断上没有太大困难，但少数病例具有一些组织病理学特征，与黑色素瘤相似，在某些情况下甚至无法区分。历史上，文献中曾使用“假黑色素瘤”一词来描述这种复发性痣，尽管这个标签可能会引起混淆，而且不再是复发性色素性黑素细胞痣的首选术语。
描述复发性色素性黑素细胞痣的历史、组织病理学和免疫组织化学特征，并简要回顾与复发机制相关的文献。
已发表的同行评议文献和作者的个人经验。
大多数情况下，病理医生识别复发性痣的组织病理学模式可做出正确诊断；然而，在特别具有挑战性的标本或临床病史不足的情况下，免疫组织化学研究已被证明有助于区分复发性痣和黑色素瘤。
