Supramaniam G, Warner J O
Lancet. 1986 Oct 18;2(8512):907-9. doi: 10.1016/s0140-6736(86)90423-x.
43 children who presented with angio-oedema and/or urticaria and who responded to an additive-free diet were challenged with artificial food additives in a double-blind study. 24 children reacted to 1 or more of the additives. 18 children did not react to any additives and remained well when a normal diet was re-introduced. Aspirin sensitivity was found in only 1 of the 24 children who could not tolerate additives. Atopy was less common in these patients than in the general population. The mechanism of additive intolerance is unknown and double-blind challenge is the only reliable means of diagnosis.
43名出现血管性水肿和/或荨麻疹且对无添加剂饮食有反应的儿童，在一项双盲研究中接受了人工食品添加剂激发试验。24名儿童对1种或更多种添加剂有反应。18名儿童对任何添加剂均无反应，重新引入正常饮食后情况良好。在24名不能耐受添加剂的儿童中，仅1名发现对阿司匹林敏感。这些患者中特应性比普通人群少见。添加剂不耐受的机制尚不清楚，双盲激发试验是唯一可靠的诊断方法。
