Botey J, Ibero M, Malet A, Marin A, Eseverri J L
Ann Allergy. 1984 Sep;53(3):265-7.
Recurrent urticaria and recurrent angioedema are frequent adverse reactions in non-atopic patients who do not tolerate aspirin. Of 1,632 infants and children who visited our allergy department for the first time, nine children (0.55%), five males and four females, presented recurrent urticaria or recurrent angioedema after taking aspirin. No evidence of atopy was disclosed either by clinical history (personal and family), skin testing, eosinophil levels or total IgE. Aspirin intolerance was established by oral challenge. Only three of the nine patients reported aspirin intolerance in their histories.
复发性荨麻疹和复发性血管性水肿是不耐受阿司匹林的非特应性患者常见的不良反应。在首次到我们过敏科就诊的1632名婴幼儿及儿童中，有9名儿童（0.55%），5名男性和4名女性，在服用阿司匹林后出现复发性荨麻疹或复发性血管性水肿。临床病史（个人及家族史）、皮肤试验、嗜酸性粒细胞水平或总IgE均未显示特应性证据。通过口服激发试验确定阿司匹林不耐受。9名患者中只有3名在其病史中报告有阿司匹林不耐受。
