Govaerts A
Pathol Biol (Paris). 1986 Jun;34(6):738-40.
Etiology of and pathogenetic mechanisms in multiple sclerosis are still badly known; therapy is thus uncertain and poorly active. Many recent studies have nevertheless shown a weak but clear association with HLA-DR2, as the possible role of a HTLV-related virus. Infection of genetically sensitive (DR2 positive) children would induce an auto-immune disease with a cellular and humoral reactivity against myelin antigens. A rather active and certainly harmless treatment consists in administration of immunoglobulins.
多发性硬化症的病因和发病机制仍鲜为人知；因此治疗方法不确定且效果不佳。然而，最近的许多研究表明，与HLA - DR2存在微弱但明确的关联，这可能是一种与人类嗜T淋巴细胞病毒（HTLV）相关病毒的作用。对基因敏感（DR2阳性）儿童的感染会诱发一种针对髓磷脂抗原具有细胞和体液反应性的自身免疫性疾病。一种相当积极且肯定无害的治疗方法是给予免疫球蛋白。
