Ravikumar Varrshine, VajraVelu Hemamalini Ramasamy, Ayyavoo Saravanan, Ramraj Balaji
Student, Department of Physiology, SRM MCH and RC, Chennai, Tamil Nadu, India.
Associate Professor, Department of Physiology, Ponnaiyah Ramajayam Institute of Medical Sciences, Kancheepuram, Chennai, Tamil Nadu, India.
J Clin Diagn Res. 2017 Jun;11(6):CC21-CC24. doi: 10.7860/JCDR/2017/27641.10062. Epub 2017 Jun 1.
Excess adiposity constitute an important public health problem because of the associated increased risk of hypertension, coronary heart disease, type 2 diabetes and other disorders. Not only the contribution of general measures of adiposity but also central measures of adiposity have been observed.
To compare and correlate the central and general adiposity indices with ventricular electrocardiographic variables and vascular stiffness indices in normal, overweight and obese young adults.
This was a cross-sectional study. Nearly ninety subjects were enrolled and were divided into 30 normal weight, 30 overweight and 30 obese group based on the BMI classification of WHO for Asian population with their age ranging from 18-25 years. Waist and hip circumferences were measured using stretchable tape. Two novel indices-conicity index and abdominal volume index were calculated using standard formula. ECG and pulse wave were recorded using the Physiopac - Medicaid systems. Statistical analysis was done using SPSS version 19.0 software. ANOVA test was done to compare the variables among three groups. Pearson's correlation coefficients were applied to establish the correlations between variables.
In our study Body Mass Index (BMI) and Conicity Index (CI) was significantly and strongly correlated with the ventricular electrocardiographic variables especially with QRS duration, QTc interval and with vascular stiffness indices. These indices can be used to assess the electrocardiographic abnormalities and vascular stiffness status.
Excess adipose tissue in young adults was closely linked to ventricular depolarization and repolarization abnormalities and also to increased vascular stiffness. Adiposity indices in particular (BMI, CI) provide a simple and non invasive approach to assess these abnormalities at the earliest in order to prevent future complications.
由于肥胖与高血压、冠心病、2型糖尿病及其他疾病的风险增加相关，肥胖已成为一个重要的公共卫生问题。不仅观察到总体肥胖指标的影响，还观察到中心性肥胖指标的影响。
比较并关联正常、超重和肥胖青年成年人的中心性和总体肥胖指数与心室心电图变量及血管僵硬度指数。
这是一项横断面研究。根据世界卫生组织针对亚洲人群的BMI分类，纳入了近90名受试者，并将其分为30名正常体重、30名超重和30名肥胖组，年龄范围为18 - 25岁。使用可拉伸卷尺测量腰围和臀围。使用标准公式计算两个新的指数——锥度指数和腹部容积指数。使用Physiopac - Medicaid系统记录心电图和脉搏波。使用SPSS 19.0软件进行统计分析。进行方差分析以比较三组之间的变量。应用Pearson相关系数来建立变量之间的相关性。
在我们的研究中，体重指数（BMI）和锥度指数（CI）与心室心电图变量尤其是QRS波时限、QTc间期以及血管僵硬度指数显著且强烈相关。这些指数可用于评估心电图异常和血管僵硬度状态。
青年成年人过多的脂肪组织与心室去极化和复极化异常以及血管僵硬度增加密切相关。尤其是肥胖指数（BMI、CI）提供了一种简单且无创的方法，可尽早评估这些异常情况，以预防未来的并发症。
