Gomez-Sanchez Leticia, Garcia-Ortiz Luis, Patino-Alonso Maria C, Recio-Rodriguez Jose I, Rigo Fernando, Martí Ruth, Agudo-Conde Cristina, Rodriguez-Sanchez Emiliano, Maderuelo-Fernandez Jose A, Ramos Rafel, Gomez-Marcos Manuel A
Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACyL), Salamanca, Spain.
Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
BMJ Open. 2017 Sep 27;7(9):e016422. doi: 10.1136/bmjopen-2017-016422.
The cardiovascular risk of obesity is potentially increased by arterial stiffness.
To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk.
Six Spanish health centres.
We enrolled 2354 adults (age range, 35-74 years; mean age, 61.4±7.7 years, 61.9% male).
This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study. The main outcome variables were body mass index (BMI), waist-to-height ratio (WHtR), Clínica Universidad de Navarra-body adiposity estimation (CUN-BAE) body fat percentage and body roundness index (BRI). Vascular function was assessed by the cardio-ankle vascular index (CAVI) with the VaSera device; brachial-ankle pulse wave velocity (baPWV) was determined using a validated equation.
The mean adiposity measures were a BMI of 29.2±4.4, WHtR of 0.61±0.07, CUN-BAE of 35.7±1.7 and BRI of 5.8±1.7. The mean stiffness measures were a CAVI of 8.8±1.2 and baPWV of 14.9±2.5. In multiple linear regression analyses, all adiposity measures were negatively associated with CAVI and baPWV (p<0.01 for all) after adjustment for possible factors of confusion. The proportion of CAVI variability via the adiposity measures were 5.5% for BMI, 5.8% for CUN-BAE, 3.8% for WHtR and 3.7% for BRI. These were higher among diabetic, obese, younger (≤62 years) and non-hypertensive subjects who had similar activity and sedentary profiles.
Adiposity measures are negatively associated with arterial stiffness measures. The percentage of variation in CAVI explained by its relation to the different measures of adiposity ranges from 5.8% (CUN-BAE) to 3.7% (BRI). In the case of baPWV, it oscillates between 0.7% (CUN-BAE and BMI) and 0.1% (WHtR).
NCT01428934.
动脉僵硬度可能会增加肥胖的心血管风险。
评估中度心血管风险的白种成年人中肥胖指标与动脉僵硬度之间的关系。
六个西班牙健康中心。
我们招募了2354名成年人（年龄范围35 - 74岁；平均年龄61.4±7.7岁，男性占61.9%）。
这是一项横断面研究，分析了改善中度风险管理（MARK）研究基线访视的数据。主要结局变量为体重指数（BMI）、腰高比（WHtR）、纳瓦拉大学临床体脂估计值（CUN - BAE）、体脂百分比和体圆度指数（BRI）。使用VaSera设备通过心踝血管指数（CAVI）评估血管功能；使用经过验证的公式确定臂踝脉搏波速度（baPWV）。
平均肥胖指标为BMI 29.2±4.4、WHtR 0.61±0.07、CUN - BAE 35.7±1.7和BRI 5.8±1.7。平均僵硬度指标为CAVI 8.8±1.2和baPWV 14.9±2.5。在多元线性回归分析中，调整可能的混杂因素后，所有肥胖指标均与CAVI和baPWV呈负相关（所有p<0.01）。通过肥胖指标解释的CAVI变异性比例，BMI为5.5%，CUN - BAE为5.8%，WHtR为3.8%，BRI为3.7%。在活动和久坐情况相似的糖尿病、肥胖、年轻（≤62岁）和非高血压受试者中，这些比例更高。
肥胖指标与动脉僵硬度指标呈负相关。CAVI与不同肥胖指标之间关系所解释的CAVI变异百分比范围为5.8%（CUN - BAE）至3.7%（BRI）。就baPWV而言，其在0.7%（CUN - BAE和BMI）至0.1%（WHtR）之间波动。
NCT01428934。
