氨甲酰胆碱能刺激离体灌注的大鼠胃释放前列腺素E2，但生长抑素或神经降压素则不能。

Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach.

作者信息

Mogard M H, Kauffman G L, Pehlevanian M, Reedy T J, Elashoff J D, Walsh J H

出版信息

Regul Pept. 1986 Aug;15(1):71-6. doi: 10.1016/0167-0115(86)90077-7.

Abstract

Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostatin and neurotensin had no effect. Combination of carbamylcholine with somatostatin or neurotensin produced no increase over that found with carbamylcholine alone. The relationship between perfusion-pressure and PGE2 release was not causal. The present findings do not support a role for prostaglandins in the mechanism of somatostatin or neurotensin action in the stomach.

摘要

在离体灌注大鼠胃中评估了氨甲酰胆碱（10⁻⁶ M）、生长抑素（10⁻¹⁰ - 10⁻⁸ M）和神经降压素（10⁻¹⁰ - 10⁻⁸ M）对前列腺素E2释放的影响。氨甲酰胆碱显著刺激胃PGE2释放并增加灌注压力，而生长抑素和神经降压素则无作用。氨甲酰胆碱与生长抑素或神经降压素联合使用时，与单独使用氨甲酰胆碱相比没有增加。灌注压力与PGE2释放之间的关系并非因果关系。目前的研究结果不支持前列腺素在胃中生长抑素或神经降压素作用机制中发挥作用。