前列腺素E2和D2对胃生长抑素及胃泌素分泌的影响。

Effects of prostaglandin E2 and D2 on gastric somatostatin and gastrin secretion.

作者信息

Takemura J, Seino Y, Nishi S, Ishida H, Sakita M, Taminato T, Chiba T, Imura H

出版信息

Regul Pept. 1983 Aug;6(4):379-84. doi: 10.1016/0167-0115(83)90267-7.

Abstract

The effects of PGE2 and PGD2 on gastric somatostatin and gastrin releases were investigated using the isolated perfused rat stomach. In the presence of 5.5 mM glucose, the infusion of PGE2 elicited a significant augmentation in somatostatin release, but suppressed gastrin secretion from the perfusate. On the other hand, PGD2 did not affect somatostatin release, although the gastrin secretion decreased significantly, the same as after PGE2 infusion. These results suggest that PGE2 and PGD2 may be important in the regulation of gastric endocrine function, but that PGD2 does not affect gastric somatostatin secretion.

摘要

采用离体灌注大鼠胃研究了前列腺素E2（PGE2）和前列腺素D2（PGD2）对胃生长抑素和胃泌素释放的影响。在存在5.5 mM葡萄糖的情况下，输注PGE2可显著增加生长抑素的释放，但抑制灌流液中胃泌素的分泌。另一方面，PGD2不影响生长抑素的释放，尽管胃泌素分泌显著减少，与输注PGE2后相同。这些结果表明，PGE2和PGD2可能在胃内分泌功能的调节中起重要作用，但PGD2不影响胃生长抑素的分泌。