前列腺素介导生长抑素对大鼠胃酸分泌的抑制作用。
Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat.
作者信息
Ligumsky M, Goto Y, Debas H, Yamada T
出版信息
Science. 1983 Jan 21;219(4582):301-3. doi: 10.1126/science.6129701.
PMID:6129701
Abstract
Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.
摘要
生长抑素是一种对胃酸分泌具有强大抑制作用的十四肽，它能增强氨甲酰胆碱诱导的前列腺素E2从离体灌注大鼠胃中的合成与释放。生长抑素抑制胃酸分泌的能力被吲哚美辛（一种前列腺素合成抑制剂）所阻断。这些结果表明，在大鼠中，前列腺素介导生长抑素对胃酸的抑制作用。
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