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血管内腹主动脉瘤修复术后影像随访依从性对死亡率的影响:一项基于人群的队列研究。

The Impact of Compliance with Imaging Follow-up on Mortality After Endovascular Abdominal Aortic Aneurysm Repair: A Population Based Cohort Study.

作者信息

de Mestral C, Croxford R, Eisenberg N, Roche-Nagle G

机构信息

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

出版信息

Eur J Vasc Endovasc Surg. 2017 Sep;54(3):315-323. doi: 10.1016/j.ejvs.2017.06.018. Epub 2017 Jul 29.

Abstract

OBJECTIVE

Compliance with regular imaging follow-up after endovascular aortic aneurysm repair (EVAR) is inconsistent, and evidence of benefit from scheduled long-term surveillance is limited. This study sought to characterize the association between post-EVAR imaging frequency and long-term survival.

METHODS

Using administrative health databases for the province of Ontario, Canada, a cohort of patients was identified who underwent EVAR between 2004 and 2014. Minimum appropriate imaging follow-up (MAIFU) was defined as a CT scan or ultrasound of the abdomen within 90 days of EVAR as well as every 15 months thereafter. Multivariate time to event analyses characterized the association between compliance with MAIFU over time and all-cause mortality.

RESULTS

4988 patients treated by EVAR were identified. Median follow-up was 3.4 years (IQR 2.0-5.3 years) and 90 day mortality was 1.6%. Among those who survived over 90 days, 87% (N = 4251 of 4902) underwent at least one CT scan or ultrasound of the abdomen within 90 days, but only 58% (N = 2859 of 4902) went on to meet MAIFU criteria. Infrequent imaging correlated with lower follow-up by a vascular surgeon, but not with infrequent primary care or specialist consultations. Consistently meeting MAIFU criteria was associated with a lower risk of death when compared with missing the first imaging follow-up within 90 days (HR 0.82, 95% CI 0.69-0.96, p = .014), or when compared with having first imaging follow-up within 90 days but subsequently not meeting MAIFU criteria (HR 0.78, 95% CI 0.68-0.91, p = .001). A larger proportion of the follow-up period meeting MAIFU criteria was associated with a lower risk of death.

CONCLUSIONS

These data support efforts to improve compliance with imaging surveillance after EVAR.

摘要

目的

血管内主动脉瘤修复术(EVAR)后定期影像学随访的依从性并不一致,且长期定期监测获益的证据有限。本研究旨在描述EVAR后影像学检查频率与长期生存之间的关联。

方法

利用加拿大安大略省的行政卫生数据库,确定了一组在2004年至2014年间接受EVAR的患者。最小适当影像学随访(MAIFU)定义为在EVAR后90天内进行腹部CT扫描或超声检查,此后每15个月进行一次。多变量事件发生时间分析描述了随时间推移符合MAIFU与全因死亡率之间的关联。

结果

共确定4988例接受EVAR治疗的患者。中位随访时间为3.4年(四分位间距2.0 - 5.3年),90天死亡率为1.6%。在存活超过90天的患者中,87%(4902例中的4251例)在90天内至少接受了一次腹部CT扫描或超声检查,但只有58%(4902例中的2859例)继续符合MAIFU标准。影像学检查不频繁与血管外科医生随访较少相关,但与初级保健或专科会诊不频繁无关。与在90天内错过首次影像学随访相比(风险比0.82,95%置信区间0.69 - 0.96,p = 0.014),或与在90天内进行首次影像学随访但随后未符合MAIFU标准相比(风险比0.78,95%置信区间0.68 - 0.91,p = 0.001),持续符合MAIFU标准与较低的死亡风险相关。符合MAIFU标准的随访期占比越大,死亡风险越低。

结论

这些数据支持为提高EVAR后影像学监测的依从性所做的努力。

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