Williams G, Fuessl H, Kraenzlin M, Bloom S R
Scand J Gastroenterol Suppl. 1986;119:73-83. doi: 10.3109/00365528609087434.
SMS 201-995 (5-100 micrograms) injected subcutaneously in normal and type-2 diabetic subjects 30 min before a test meal caused dose-related suppression of plasma concentrations of insulin, glucagon, and several regulatory gut peptide hormones (gastrin, gastric inhibitory peptide, pancreatic polypeptide, secretin, neurotensin, and motilin). Effective hormone suppression was achieved even at the lowest dose of 5 micrograms. In the normal subjects SMS caused postprandial hyperglycaemia, but there was no overall deterioration in glucose tolerance in the type-2 diabetic patients. This suggests that counterregulatory hormones play an important part in the metabolic disturbance of type-2 diabetes.
在正常受试者和2型糖尿病患者的试验餐之前30分钟，皮下注射SMS 201 - 995（5 - 100微克）可导致胰岛素、胰高血糖素以及几种调节性肠肽激素（胃泌素、胃抑肽、胰多肽、促胰液素、神经降压素和胃动素）的血浆浓度出现剂量相关的抑制。即使在最低剂量5微克时也能有效抑制激素。在正常受试者中，SMS导致餐后高血糖，但2型糖尿病患者的糖耐量并未整体恶化。这表明反调节激素在2型糖尿病的代谢紊乱中起重要作用。
