Fuessl H S, Burrin J M, Williams G, Adrian T E, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, London, UK.
Aliment Pharmacol Ther. 1987 Aug;1(4):321-30. doi: 10.1111/j.1365-2036.1987.tb00632.x.
SMS 201-995 is an octapeptide analogue of somatostatin. The effect of a single subcutaneous (s.c.) injection of 50 micrograms SMS 201-995 on post-prandial intermediary metabolism was investigated in normal subjects. In spite of a long-lasting post-prandial suppression of insulin secretion, there were no significant changes in the plasma concentration of alanine, glycerol, 3-OH-butyrate or lactate. However, SMS 201-995 impairs carbohydrate tolerance, probably due to inhibition of insulin secretion. Basal and post-prandial plasma concentrations of the gut regulatory peptides pancreatic glucagon, motilin, pancreatic polypeptide, gastric inhibitory polypeptide, enteroglucagon, gastrin and peptide YY were suppressed up to 5 hours after subcutaneous administration of a single dose of SMS 201-995.
SMS 201-995是一种生长抑素的八肽类似物。在正常受试者中研究了单次皮下注射50微克SMS 201-995对餐后中间代谢的影响。尽管餐后胰岛素分泌受到长期抑制，但丙氨酸、甘油、3-羟基丁酸或乳酸的血浆浓度没有显著变化。然而，SMS 201-995损害糖耐量，可能是由于胰岛素分泌受到抑制。单次皮下注射SMS 201-995后长达5小时，肠道调节肽胰高血糖素、胃动素、胰多肽、胃抑制多肽、肠高血糖素、胃泌素和肽YY的基础和餐后血浆浓度均受到抑制。
