Leung Janet Y, Kim William Y
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Cancer Discov. 2017 Aug;7(8):802-804. doi: 10.1158/2159-8290.CD-17-0610.
Large genome sequencing efforts have identified frequent mutations in the histone-modifying and chromatin-remodeling genes and in clear cell renal cell carcinoma (ccRCC). In this issue of , Gu and colleagues model these genetic events in mice and report that dual inactivation of with either or results in faithful genetically engineered murine models of ccRCC. Moreover, their work establishes that and are determinants of tumor grade and mTORC1 activation and provocatively suggests that the cell of origin of ccRCC may lie in PAX8-expressing Bowman capsule cells. .
大规模基因组测序工作已在组蛋白修饰和染色质重塑基因以及透明细胞肾细胞癌(ccRCC)中发现了频繁的突变。在本期杂志中,顾及其同事在小鼠中模拟了这些遗传事件,并报告称,与 或 双重失活会产生忠实的ccRCC基因工程小鼠模型。此外,他们的工作证实 和 是肿瘤分级和mTORC1激活的决定因素,并颇具启发性地表明,ccRCC的起源细胞可能位于表达PAX8的鲍曼囊细胞中。