Department of Stomatology, Jinan Central Hospital, Shandong University, Jinan, 250013, P.R. China.
Division of Conservative Dentistry and Periodontology, School of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090 Vienna, Austria.
Sci Rep. 2017 Aug 1;7(1):7027. doi: 10.1038/s41598-017-06937-y.
Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.
种植体周围病是一种由细菌感染引起的种植体周围软硬组织的慢性炎症。最近的证据表明，免疫细胞释放的一些促炎细胞因子和趋化因子在炎症的进展和后果中起主要作用。高迁移率族蛋白 B1（HMGB1）在损伤、坏死和炎症时释放到细胞外基质中，并作为关键的促炎因子发挥作用。在来自炎症性牙龈组织的龈沟液中发现 HMGB1 的浓度高于健康部位。用脂多糖（LPS）和白细胞介素-1β刺激小鼠牙周膜成纤维细胞后，HMGB1mRNA 和蛋白表达上调。因此，本研究旨在评估种植体周围疾病各个阶段种植体周围龈沟液（PICF）中 HMGB1 的表达，并探讨 HMGB1 与种植体周围疾病进展的相关性。结果表明，PICF 中 HMGB1 的表达水平提示种植体周围疾病的进展，因此可能是一种有用的种植体组织诊断和预后生物标志物。
