使用离子通道阻滞剂模拟心房颤动期间的心室率控制。
Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers.
作者信息
Inada Shin, Shibata Md PhD Nitaro, Iwata PhD Michiaki, Haraguchi PhD Ryo, Ashihara Md PhD Takashi, Ikeda Md PhD Takanori, Mitsui PhD Kazuyuki, Dobrzynski PhD Halina, Boyett PhD Mark R, Nakazawa PhD Kazuo
机构信息
Himeji Dokkyo University, Himeji, Hyogo, Japan.
Shinjuku Mitsui Building Clinic, Tokyo, Japan.
出版信息
J Arrhythm. 2017 Aug;33(4):302-309. doi: 10.1016/j.joa.2016.12.002. Epub 2017 Jan 22.
BACKGROUND
The atrioventricular (AV) node is the only compartment that conducts an electrical impulse between the atria and the ventricles. The main role of the AV node is to facilitate efficient pumping by conducting excitation slowly between the two chambers as well as reduce the ventricular rate during atrial fibrillation (AF).
METHODS
Using computer simulations, we investigated excitation conduction from the right atrium to the bundle of His during high-rate atrial excitation with or without partial blocking of the calcium or potassium ionic current.
RESULTS
Our simulations revealed differences in rate reduction and repolarization effects between calcium and potassium current blocking and high degree of potassium current blocking required to reduce the ventricular rate during AF.
CONCLUSIONS
Our simulation results explain why potassium current blockers are not recommended for controlling ventricular rate during AF.
背景
房室（AV）结是心房和心室之间传导电冲动的唯一腔室。房室结的主要作用是通过在两个腔室之间缓慢传导兴奋来促进有效泵血，并在心房颤动（AF）期间降低心室率。
方法
我们使用计算机模拟，研究了在高速心房兴奋期间，有或没有部分阻断钙或钾离子电流时，从右心房到希氏束的兴奋传导。
结果
我们的模拟揭示了钙电流和钾电流阻断之间在心率降低和复极化效应方面的差异，以及在心房颤动期间降低心室率所需的高度钾电流阻断。
结论
我们的模拟结果解释了为什么不建议使用钾电流阻滞剂来控制心房颤动期间的心室率。
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