Boyadjieva N, Ovcharov R, Visheva N, Milanov S
Acta Physiol Pharmacol Bulg. 1986;12(2):3-6.
Pharmacological studies of the effect of Diazepam and Medazepam on prolactin secretion were carried out on sexually mature male albino rats. The experiments were carried out using two series of experimental set-ups. In the first series an analysis was made of the effect of Diazepam in doses of 2 and 4 mg/kg body mass, and of Medazepam in doses of 1 and 10 mg/kg body mass, on the prolactin secretion on the 60th min after a single intraperitoneal injection. The second series of experiments was designed to investigate the effect of Diazepam and Medazepam in the same doses under conditions of acute immobilization of the animals for 60 min. The prolactin levels in the serum were tested using a radioimmunological method. Prolactin secretion decreases after a single intraperitoneal administration of Diazepam in both doses. Prolactin content in the serum was reduced only after a dose of 10 mg/kg body mass. Under conditions of experimental immobilization stress, prolactin secretion was stimulated in the animals from the control group, treated with standard solution used as solvent. Diazepam in both doses administered and Medazepam in a dose of 10 mg/kg inhibit the prolactin secretion stimulated by acute immobilization stress.
在地西泮和去甲西泮对催乳素分泌影响的药理学研究中，选用了性成熟的雄性白化大鼠。实验采用了两组实验装置。在第一组实验中，分析了腹腔注射单次给药后第60分钟时，2毫克/千克体重和4毫克/千克体重剂量的地西泮以及1毫克/千克体重和10毫克/千克体重剂量的去甲西泮对催乳素分泌的影响。第二组实验旨在研究在动物急性固定60分钟的条件下，相同剂量的地西泮和去甲西泮的作用。采用放射免疫法检测血清中的催乳素水平。两种剂量的地西泮单次腹腔给药后催乳素分泌均减少。仅在10毫克/千克体重剂量下血清中的催乳素含量降低。在实验性固定应激条件下，用作为溶剂的标准溶液处理的对照组动物的催乳素分泌受到刺激。两种剂量的地西泮和10毫克/千克体重剂量的去甲西泮均抑制急性固定应激刺激的催乳素分泌。
