Stancheva S, Petkov V V
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Acta Physiol Pharmacol Bulg. 1988;14(3):26-31.
Studies were made of the effect of 19-day administration of diazepam (1 mg.kg-1, i.p.) and medazepam (5 mg.kg-1, i.p.) on the level of biogenic monoamines in different rat brain areas: cerebral cortex, striatum, hippocampus, and hypothalamus. The noradrenaline (NA), dopamine (DA) and serotonin (5-HT) levels were determined. After chronic treatment with diazepam no alterations in the NA content in the cortex, striatum and hypothalamus were found. Medazepam increased the NA level in the cortex, striatum, and hippocampus without changing it in the hypothalamus. Repeated administration of diazepam or medazepam led to an increase in the DA level in the striatum. Both benzodiazepines provoked a significant increase in the hippocampal 5-HT level, which could be attributed to the antianxiety effect of these drugs.
研究了连续19天腹腔注射地西泮（1毫克/千克）和美达西泮（5毫克/千克）对大鼠不同脑区（大脑皮层、纹状体、海马体和下丘脑）生物源性单胺水平的影响。测定了去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）的水平。长期用地西泮治疗后，未发现皮层、纹状体和下丘脑的NA含量有变化。美达西泮可提高皮层、纹状体和海马体中的NA水平，而下丘脑的NA水平无变化。反复注射地西泮或美达西泮可使纹状体中的DA水平升高。两种苯二氮䓬类药物均可使海马体中的5-HT水平显著升高，这可能归因于这些药物的抗焦虑作用。
