[血友病患者的血栓形成事件]
[Thrombotic events in patients with hemophilia].
作者信息
Galstyan G M, Polevodova O A, Gavrish A Yu, Polyanskaya T Yu, Zorenko V Yu, Sampiev M S, Biryukova L S, Model S V, Gorgidze L A, Savchenko V G
机构信息
National Research Center for Hematology, Ministry of Health of Russia, Moscow, Russia.
出版信息
Ter Arkh. 2017;89(7):76-84. doi: 10.17116/terarkh201789776-84.
The paper describes 4 clinical cases of thrombotic events (pulmonary embolism, deep vein thrombophlebitis, acute myocardial infarction, ischemic stroke) that have occurred in patients with hemophilia. It discusses the possible causes of their development and methods for their prevention and treatment. Controlled natural hypocoagulation, in which the dose of an administered deficient factor decreases to such an extent that in order to maintain the safe level of hypocoagulation (plasma factor activity is 15-20%; activated partial thromboplastin time is 1.5-2 times normal values), is proposed as one of the treatment options.
该论文描述了4例血友病患者发生血栓形成事件（肺栓塞、深静脉血栓性静脉炎、急性心肌梗死、缺血性中风）的临床病例。论文讨论了这些事件发生的可能原因以及预防和治疗方法。作为治疗选择之一，提出了可控性自然低凝，即所给予的缺乏因子的剂量降低到一定程度，以维持安全的低凝水平（血浆因子活性为15% - 20%；活化部分凝血活酶时间为正常值的1.5 - 2倍）。
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