Zhu Yicheng, Uezono Naohiro, Yasui Tetsuro, Nakashima Kinichi
Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Dev Dyn. 2018 Jan;247(1):75-84. doi: 10.1002/dvdy.24558. Epub 2017 Sep 6.
Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75-84, 2018. © 2017 Wiley Periodicals, Inc.
脊髓损伤会导致轴突纤维横断和神经细胞死亡，从而破坏神经网络并造成严重的功能丧失。由于成年哺乳动物中枢神经系统的再生能力非常差，受损神经回路的重建曾一度被认为是毫无希望的。因此，目前尚无针对脊髓损伤（SCI）的有效治疗方法。然而，随着干细胞研究和细胞培养技术的最新进展，使用神经干细胞（NSC）移植的再生疗法迅速发展起来，这种治疗策略使得重建被破坏的神经回路成为可能。在这篇综述中，我们讨论了NSC移植治疗SCI的最新突破。《发育动力学》247:75 - 84, 2018年。© 2017威利期刊公司。
