抑制蛋白-蛋白相互作用：开发针对被忽视热带病药物的新选择。
Inhibition of Protein-Protein Interactions: New Options for Developing Drugs against Neglected Tropical Diseases.
机构信息
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany.
出版信息
Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12048-12050. doi: 10.1002/anie.201706479. Epub 2017 Aug 2.
PMID:28766862
Abstract
Wake up! Sleeping sickness and Chagas disease are neglected tropical diseases caused by trypanosome infections. Small molecules that disrupt a crucial protein-protein interaction in the parasites offer a new approach to drug development for these diseases.
摘要
醒醒！昏睡病和恰加斯病都是由锥虫感染引起的被忽视的热带病。破坏寄生虫中关键蛋白-蛋白相互作用的小分子为这些疾病的药物研发提供了新方法。
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