Grupo de Investigación en Química Orgánica y Biomedica, Programa de Química, Facultad de Ciencias Basicas, Universidad del Atlántico, A.A.1890, Barranquilla, Colombia.
Curr Top Med Chem. 2024;24(2):89-108. doi: 10.2174/0115680266256963230921061925.
Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic infections caused by , and .
本文综述了天然产物类分子作为抗疟原虫、利什曼病（LE）、恰加斯病（CD）和非洲人类锥虫病（HAT）的抗寄生虫药物的最新研究进展。本文除了分析天然产物作为活性物质的结构多样性和在 CD、HAT、LE 和疟疾中的多种生物应用外，还讨论了不同植物在开发生物活性物质方面的作用。本文重点介绍了药物化学，强调了天然分子作为针对 和 引起的寄生虫感染的生物活性物质的结构特征。
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