探索天然产物作为治疗被忽视热带病的抗寄生虫药物的潜力。

Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases.

机构信息

Grupo de Investigación en Química Orgánica y Biomedica, Programa de Química, Facultad de Ciencias Basicas, Universidad del Atlántico, A.A.1890, Barranquilla, Colombia.

出版信息

Curr Top Med Chem. 2024;24(2):89-108. doi: 10.2174/0115680266256963230921061925.

DOI:10.2174/0115680266256963230921061925

PMID:37842892

Abstract

Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic infections caused by , and .

摘要

本文综述了天然产物类分子作为抗疟原虫、利什曼病（LE）、恰加斯病（CD）和非洲人类锥虫病（HAT）的抗寄生虫药物的最新研究进展。本文除了分析天然产物作为活性物质的结构多样性和在 CD、HAT、LE 和疟疾中的多种生物应用外，还讨论了不同植物在开发生物活性物质方面的作用。本文重点介绍了药物化学，强调了天然分子作为针对和引起的寄生虫感染的生物活性物质的结构特征。