持续气道正压通气对顽固性高血压合并阻塞性睡眠呼吸暂停患者血压的影响：六项随机对照试验的系统评价和荟萃分析

Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials.

作者信息

Lei Qiang, Lv Yunhui, Li Kai, Ma Lei, Du Guodong, Xiang Yan, Li Xuqing

机构信息

. Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, China.

. Department of Respiratory Medicine, First People's Hospital of Yunnan Province, Kunming, China.

出版信息

J Bras Pneumol. 2017 Sep-Oct;43(5):373-379. doi: 10.1590/S1806-37562016000000190. Epub 2017 Jul 31.

OBJECTIVE

To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA).

METHODS

The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity.

RESULTS

Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were -5.40 mmHg (95% CI: -9.17 to -1.64; p = 0.001; I2 = 74%) and -3.86 mmHg (95% CI: -6.41 to -1.30; p = 0.00001; I2 = 79%), respectively.

CONCLUSIONS

CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA.

目的

系统评价持续气道正压通气（CPAP）对顽固性高血压合并阻塞性睡眠呼吸暂停（OSA）患者血压的影响。

方法

检索考克兰图书馆、PubMed、ScienceDirect和科学引文索引数据库，查找有关CPAP对顽固性高血压合并OSA患者血压影响的研究。对所选研究进行质量评估和荟萃分析，并检测异质性。

结果

荟萃分析纳入6项随机对照试验。平均收缩压和平均舒张压变化的合并估计值（通过24小时动态血压监测评估）分别为-5.40 mmHg（95%可信区间：-9.17至-1.64；p = 0.001；I² = 74%）和-3.86 mmHg（95%可信区间：-6.41至-1.30；p = 0.00001；I² = 79%）。