Science for Life Laboratory, KTH-Royal Institute of Technology, 17165 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, 41260 Gothenburg, Sweden.
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Cell Metab. 2017 Aug 1;26(2):281-283. doi: 10.1016/j.cmet.2017.07.006.
Plasma mannose levels are elevated in subjects with insulin resistance independently of obesity. Here, we found that elevated plasma mannose levels are strong markers of future risk of several chronic diseases including T2D, CVD, and albuminuria, and that it may contribute to their development rather than just being a novel biomarker.
血浆甘露糖水平在胰岛素抵抗患者中升高,而与肥胖无关。在这里,我们发现升高的血浆甘露糖水平是多种慢性疾病(包括 T2D、CVD 和白蛋白尿)未来风险的强烈标志物,它可能导致这些疾病的发生,而不仅仅是一种新的生物标志物。