Min Lillian, Hall Karen, Finlayson Emily, Englesbe Michael, Palazzolo William, Chan Chiao-Li, Hou Hechuan, Miller Ashley, Diehl Kathleen M
Division of Geriatric and Palliative Medicine, Department of Medicine, University of Michigan, Ann Arbor.
Geriatric Research Education Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan.
JAMA Surg. 2017 Dec 1;152(12):1126-1133. doi: 10.1001/jamasurg.2017.2635.
As greater numbers of older patients seek elective surgery, one approach to preventing postoperative complications is enhanced assessment of risks during preoperative evaluation.
To determine whether a geriatric assessment tool can be implemented in a preoperative clinic and can estimate risk of postoperative complications.
DESIGN, SETTING, AND PARTICIPANTS: In this prospective cohort study, patients 70 years of age or older were assessed in a preoperative clinic for elective surgery from July 9, 2008, to January 5, 2011. Patients were screened using the Vulnerable Elders Surgical Pathways and Outcomes Assessment (VESPA) tool developed for this study. Patients were assessed on 5 preoperative activities of daily living recommended by the American College of Surgeons (bathing, transferring, dressing, shopping, and meals), history of falling or gait impairment, and depressive symptoms (2-item Patient Health Questionnaire). Patients also underwent a brief cognitive examination (Mini-Cog) and gait and balance assessment (Timed Up and Go test). A novel question was also asked as to whether patients expected they could manage themselves alone after discharge. Comorbidities and work-related relative value units (categorized into low, moderate, and high tertiles) were also collected. Multivariable logistic regression was performed to estimate risk of postoperative complications. Sustainability of VESPA over time was also evaluated. Medical record review was performed from December 11, 2012, to October 2, 2015, and data analysis was performed from November 15, 2015, to May 18, 2016.
Postoperative surgical and geriatric complications.
Of the 770 patients evaluated, 736 (384 women and 352 men; mean [SD] age, 77.7 [5.7] years) underwent 740 operative procedures; of these patients, 711 had complete data for multivariable analysis. In our sample, 105 patients (14.3%) reported 1 or more difficulties with the 5 activities of daily living, and 270 of 707 patients (38.2%) foresaw themselves unable to manage self-care alone. A total of 131 of 740 patients had geriatric complications, and 114 of 740 patients had surgical complications; 187 of 740 patients (25.3%) had either geriatric or surgical complications. On multivariable analysis, the number of difficulties with activities of daily living (odds ratio [OR], 1.3; 95% CI, 1.0-1.6), anticipated difficulty with postoperative self-care (OR, 1.6; 95% CI, 1.0-2.2), Charlson Comorbidity score of 2 or more vs less than 2 (OR, 1.5; 95% CI, 1.0-2.3), male sex (OR, 1.6; 95% CI, 1.1-2.3), and work-related relative value units (moderate vs low: OR, 1.9; 95% CI, 1.1-3.3; high vs low: OR, 8.8; 95% CI, 5.3-14.5) were independently associated with postoperative complications (overall model area under the receiver operating characteristic curve, 0.77). With these results, a whole-point VESPA score used alone to estimate risk of complications also demonstrated excellent fit (area under the curve, 0.76).
Preoperative assessment of older geriatric patients is feasible in the general preoperative clinic and can help identify patients at higher risk of postoperative complications.
随着越来越多的老年患者寻求择期手术,术前评估期间加强风险评估是预防术后并发症的一种方法。
确定老年评估工具是否可在术前诊所实施,并能否估计术后并发症风险。
设计、地点和参与者:在这项前瞻性队列研究中,2008年7月9日至2011年1月5日期间,在术前诊所对70岁及以上的患者进行择期手术评估。使用为本研究开发的脆弱老年人手术途径和结果评估(VESPA)工具对患者进行筛查。根据美国外科医师学会推荐的5项术前日常生活活动(洗澡、转移、穿衣、购物和用餐)、跌倒或步态障碍病史以及抑郁症状(2项患者健康问卷)对患者进行评估。患者还接受了简短的认知检查(简易认知评估量表)和步态及平衡评估(起立行走测试)。还询问了一个新问题,即患者是否期望出院后能够独自自理。还收集了合并症和与工作相关的相对价值单位(分为低、中、高三分位)。进行多变量逻辑回归以估计术后并发症风险。还评估了VESPA随时间的可持续性。2012年12月11日至2015年10月2日进行病历审查,2015年11月15日至2016年5月18日进行数据分析。
术后手术和老年并发症。
在770名接受评估的患者中,736名(384名女性和352名男性;平均[标准差]年龄,77.7[5.7]岁)接受了740例手术;在这些患者中,711名有完整数据用于多变量分析。在我们的样本中,105名患者(14.3%)报告在5项日常生活活动中有1项或更多困难,707名患者中有270名(38.2%)预计自己无法独自进行自我护理。740名患者中共有131名发生老年并发症,740名患者中有114名发生手术并发症;740名患者中有187名(25.3%)发生老年或手术并发症。在多变量分析中,日常生活活动困难数量(比值比[OR],1.3;95%置信区间,1.0 - 1.6)、术后自我护理预期困难(OR,1.6;95%置信区间,1.0 - 2.2)、Charlson合并症评分2分及以上与低于2分(OR,1.5;95%置信区间,1.0 - 2.3)、男性(OR,1.6;95%置信区间,1.1 - 2.3)以及与工作相关的相对价值单位(中等与低:OR,1.9;95%置信区间,1.1 - 3.3;高与低:OR,8.8;95%置信区间,5.3 - 14.5)与术后并发症独立相关(总体模型受试者工作特征曲线下面积,0.77)。根据这些结果,单独使用VESPA总分来估计并发症风险也显示出良好的拟合度(曲线下面积,0.76)。
在普通术前诊所对老年患者进行术前评估是可行的,并且有助于识别术后并发症风险较高的患者。