Burioka Naoto, Nakamoto Sachiko, Amisaki Takashi, Horie Takuya, Shimizu Eiji
Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Japan.
Department of Biological Regulation, School of Health Science, Tottori University Faculty of Medicine, Japan.
Intern Med. 2017;56(15):1949-1955. doi: 10.2169/internalmedicine.56.7961. Epub 2017 Aug 1.
Objective The 6-min walk test (6MWT) is a simple test that is used to examine the exercise tolerance and outcomes in patients with chronic obstructive pulmonary disease (COPD). Although the 6MWT is useful for assessing exercise tolerance, it is difficult to evaluate time-dependent parameters such as the walking pattern. A modified 6MWT has been devised to assess the walking pattern by calculating the number of steps per second (NSPS). This study was performed to investigate walking pattern of COPD patients in the modified 6MWT before and after a single inhalation of the short-acting β-agonist procaterol. Methods Nine male COPD patients participated in this study. The 6MWT was performed before and after the inhalation of procaterol hydrochloride. A digital video recording of the 6MWT was made. After the 6MWT, the number of steps walked by the subject in each 5-s period was counted manually with a hand counter while viewing the walking test on the video monitor. Results After the inhalation of procaterol, the 6-min walking distance increased significantly in comparison to baseline (p<0.01). The mean NSPS was also significantly increased after the inhalation of procaterol in comparison to baseline (p<0.01). The walking pattern was displayed on a graph of time versus NSPS, and the walking pace was shown by a graph of time versus cumulative steps. Conclusion The analysis of the COPD patients' walking test performance and their walking pattern and pace in the 6MWT may help to evaluate the effects of drug treatment.
目的 6分钟步行试验（6MWT）是一项用于检查慢性阻塞性肺疾病（COPD）患者运动耐力和预后的简单试验。尽管6MWT对评估运动耐力有用，但难以评估诸如步行模式等时间依赖性参数。已设计出一种改良的6MWT，通过计算每秒步数（NSPS）来评估步行模式。本研究旨在调查单次吸入短效β受体激动剂丙卡特罗前后，COPD患者在改良6MWT中的步行模式。方法 9名男性COPD患者参与本研究。在吸入丙卡特罗前后进行6MWT。对6MWT进行数字视频记录。6MWT结束后，在视频监视器上观看步行试验时，用手动计数器手动计算受试者在每5秒时间段内行走的步数。结果 吸入丙卡特罗后，6分钟步行距离与基线相比显著增加（p<0.01）。与基线相比，吸入丙卡特罗后平均NSPS也显著增加（p<0.01）。步行模式显示在时间与NSPS的图表上，步行速度由时间与累积步数的图表显示。结论 分析COPD患者在6MWT中的步行试验表现、步行模式和速度可能有助于评估药物治疗效果。
