与混合性结缔组织病相关的蛋白丢失性胃肠病：一例成功治疗病例报告及文献综述
Protein-losing Gastroenteropathy Related to Mixed Connective Tissue Disease: A Case Report of a Successful Outcome and Literature Review.
作者信息
Kobayashi Yuya, Shimojima Yasuhiro, Kondo Yasufumi, Takamatsu Ryota, Miyazaki Daigo, Kishida Dai, Sekijima Yoshiki, Ikeda Shu-Ichi
机构信息
Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Japan.
出版信息
Intern Med. 2017;56(15):2057-2062. doi: 10.2169/internalmedicine.56.8391. Epub 2017 Aug 1.
We herein report the case of a 44-year-old woman who developed protein-losing gastroenteropathy (PLGE) with hypoalbuminemia as the first manifestation of mixed connective tissue disease (MCTD). Albumin leakage from the stomach and intestinal tract was demonstrated by Tc-labeled human serum albumin scintigraphy. The patient's response to prednisolone therapy was insufficient; therefore, additional cyclosporin A (CsA) treatment was administered, and clinical remission was achieved. We concluded that although PLGE is a rare complication of MCTD, it may manifest as an initial clinical episode of MCTD. Furthermore, CsA can be a useful treatment option for refractory PLGE related to MCTD.
我们在此报告一例44岁女性，其以蛋白丢失性胃肠病（PLGE）伴低白蛋白血症作为混合性结缔组织病（MCTD）的首发表现。锝标记的人血清白蛋白闪烁扫描显示胃和肠道有白蛋白渗漏。患者对泼尼松龙治疗反应不足；因此，加用环孢素A（CsA）治疗，实现了临床缓解。我们得出结论，虽然PLGE是MCTD的罕见并发症，但它可能表现为MCTD的初始临床发作。此外，CsA可能是治疗与MCTD相关的难治性PLGE的有用选择。
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