Klem K, Murray G R, Laake K
Eur J Clin Pharmacol. 1986;30(6):745-7. doi: 10.1007/BF00608229.
A single dose of temazepam 10 mg, as a solution in soft gelatin capsules, was given to 10 fasting geriatric in-patients (mean age 83 years) in a stable clinical condition. The mean peak plasma concentration was 306 ng/ml, with a median time of 0.75 h to peak concentration. Temazepam was eliminated from plasma in a biexponential manner, with a distribution phase (mean t1/2 alpha = 0.7 h) predominating for 3 h. The drug had a mean elimination half-life of 8.7 h. In a chronic study, in which temazepam 10 mg p.o. was given nightly to 13 patients, the plasma concentrations on Days 3, 5, 8, 12 and 15 were not significantly different from each other, showing rapid attainment of steady state levels and the lack of drug accumulation.
给10名处于稳定临床状态的空腹老年住院患者（平均年龄83岁）服用单剂量10毫克的替马西泮软胶囊溶液。平均血浆峰浓度为306纳克/毫升，达到峰浓度的中位时间为0.75小时。替马西泮以双指数方式从血浆中消除，分布相（平均t1/2α=0.7小时）占主导地位达3小时。该药物的平均消除半衰期为8.7小时。在一项慢性研究中，每晚给13名患者口服10毫克替马西泮，第3、5、8、12和15天的血浆浓度彼此无显著差异，表明迅速达到稳态水平且无药物蓄积。
