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IMMUNOPHENOTYPING OF ACUTE LEUKAEMIAS : A CRITICAL ANALYSIS OF 35 CASES.急性白血病的免疫表型分析：35例病例的批判性分析
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Immunophenotypic analysis of acute leukemia.急性白血病的免疫表型分析
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Immunologically defined subclasses of acute lymphoblastic leukaemia in children: their relationship to presentation features and prognosis.儿童急性淋巴细胞白血病的免疫学分型：其与临床表现特征及预后的关系
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Immunologic diagnosis and monitoring of human acute leukemias: a review.人类急性白血病的免疫诊断与监测：综述
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Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).使用碱性磷酸酶与单克隆抗碱性磷酸酶的免疫复合物（碱性磷酸酶抗碱性磷酸酶复合物，APAAP复合物）对单克隆抗体进行免疫酶标记。
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The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.注入的辣根过氧化物酶在小鼠肾近端小管吸收的早期阶段：一种新技术的超微结构细胞化学研究
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Minimally differentiated acute nonlymphocytic leukemia: a distinct entity.微分化急性非淋巴细胞白血病：一种独特的实体。
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Classifying acute leukemia by immunophenotyping: a combined FAB-immunologic classification of AML.通过免疫表型分析对急性白血病进行分类：急性髓系白血病的FAB-免疫联合分类
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The role of ultrastructural cytochemistry and monoclonal antibodies in clarifying the nature of undifferentiated cells in acute leukaemia.
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急性白血病的免疫表型分析：35例病例的批判性分析

IMMUNOPHENOTYPING OF ACUTE LEUKAEMIAS : A CRITICAL ANALYSIS OF 35 CASES.

作者信息

Kumar Harsh, Kumar Rajat, Sivadas P, Panayach J S, Rao R Ranga, Bhardwaj J R

机构信息

Reader in Pathology, AFMC, Pune.

Reader in Medicine, AFMC, Pune.

出版信息

Med J Armed Forces India. 1995 Jul;51(3):165-169. doi: 10.1016/S0377-1237(17)30958-9. Epub 2017 Jun 26.

DOI:10.1016/S0377-1237(17)30958-9
PMID:28769280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5530029/
Abstract

Accurate classification of acute leukaemias is essential for proper case management. The utility of monoclonal antibodies in the diagnosis and classification of acute leukaemias is well established. This diagnostic utility relates primarily to two points : firstly the distinction between acute myeloid leukaemia and acute lymphoblastic leukaemia and secondly to subtypes of acute lymphoblastic leukaemia. Leukaemic cells were immunophenotyped using the alkaline phosphatase antialkaline phosphatase techniques. The monoclonal antibodies were very useful in distinguishing cases of acute myeloid leukaemia from acute lymphoblastic leukaemia. Cases of acute lymphoblastic leukaemia with CD10 positivity showed a better prognosis. T-cell acute lymphoblastic leukaemia was uncommon and was associated with unfavourable prognosis. The alkaline phosphatase antialkaline phosphatase technique served as a reliable and convenient method for immunophenotyping of leukaemias.

摘要

急性白血病的准确分类对于恰当的病例管理至关重要。单克隆抗体在急性白血病的诊断和分类中的效用已得到充分证实。这种诊断效用主要涉及两点：第一，急性髓系白血病与急性淋巴细胞白血病之间的区分；第二，急性淋巴细胞白血病的亚型。采用碱性磷酸酶抗碱性磷酸酶技术对白血病细胞进行免疫表型分析。单克隆抗体在区分急性髓系白血病和急性淋巴细胞白血病病例方面非常有用。CD10阳性的急性淋巴细胞白血病病例预后较好。T细胞急性淋巴细胞白血病不常见，且预后不良。碱性磷酸酶抗碱性磷酸酶技术是白血病免疫表型分析的一种可靠且便捷的方法。