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耐药结核病——新出现的情况

DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO.

作者信息

Jena J, Nema S K, Panda B N

机构信息

Classified Specialists Pathology, Military Hospital (CTC), Pune 411 040.

Classified Specialist Medicine & Chest Diseases, Military Hospital (CTC), Pune 411 040.

出版信息

Med J Armed Forces India. 1996 Apr;52(2):87-90. doi: 10.1016/S0377-1237(17)30850-X. Epub 2017 Jun 26.

DOI:10.1016/S0377-1237(17)30850-X
PMID:28769352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5530262/
Abstract

During the period April 1992 to September 1994 a total of 2288 patients of pulmonary tuberculosis were treated at our centre. could be isolated from the sputa of 1037 patients (45.3%). All the isolates were subjected to indirect susceptibility testing using drug incorporated Lowenstein-Jensen medium slants. A total of 142 (13.7%) patients showed drug resistance. Single drug resistance was observed in 86 (8.3%) patients whereas resistance to two or more drugs was observed in 56 (5.4%) patients. Patients showing initial drug resistance were more in number (83 cases) than those showing acquired drug resistance (59 cases). Resistance to streptomycin was commonest (8.3% of isolates) followed by isoniazid (5.7%) and rifampicin (5.0%). Multiple drug resistance was mostly acquired (71.4% of drug-resistant isolates).

摘要

在1992年4月至1994年9月期间，我们中心共治疗了2288例肺结核患者。从1037例患者（45.3%）的痰液中分离出了病菌。所有分离出的病菌都采用含药的罗氏培养基斜面进行间接药敏试验。共有142例（13.7%）患者显示出耐药性。86例（8.3%）患者观察到单药耐药，而56例（5.4%）患者观察到对两种或更多药物耐药。显示初始耐药的患者数量（83例）多于获得性耐药的患者（59例）。对链霉素耐药最为常见（占分离菌株的8.3%），其次是异烟肼（5.7%）和利福平（5.0%）。多重耐药大多是获得性的（占耐药菌株的71.4%）。

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Initial therapy for tuberculosis in the era of multidrug resistance. Recommendations of the Advisory Council for the Elimination of Tuberculosis.耐多药时代的结核病初始治疗。消除结核病咨询委员会的建议。
MMWR Recomm Rep. 1993 May 21;42(RR-7):1-8.
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Treatment of multidrug-resistant tuberculosis.耐多药结核病的治疗
N Engl J Med. 1993 Sep 9;329(11):784-91. doi: 10.1056/NEJM199309093291108.
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Primary tuberculosis in children. 2. Correlation of susceptibility patterns of M. tuberculosis isolated from children with those isolated from source cases as an index of drug-resistant infection in a community.儿童原发性结核病。2. 将从儿童分离出的结核分枝杆菌的药敏模式与从传染源分离出的结核分枝杆菌的药敏模式进行相关性分析，以此作为社区耐药感染的指标。
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