Buraczynska M, Hanzlik J, Grzywa M
Hum Genet. 1986 Oct;74(2):165-7. doi: 10.1007/BF00282082.
A genetic analysis of atherosclerotic patients as well as healthy subjects using an apoA-I gene specific probe confirmed that an EcoRI restriction fragment length polymorphism is related to the development of atherosclerosis. Three subjects with severe coronary heart disease were found to be homozygous for a 6.5 kb fragment hybridizing to the apoA-I probe. In the atherosclerotic patient group 44% were heterozygous for this fragment, compared to 9.5% in the control group. The distribution of genotypes in the atherosclerotic and control groups was significantly different. Among the heterozygous subjects, specific differences were found after digestion of their DNA with Bam HI restriction endonuclease.
使用载脂蛋白A-I基因特异性探针，对动脉粥样硬化患者和健康受试者进行的基因分析证实，EcoRI限制性片段长度多态性与动脉粥样硬化的发生发展有关。发现三名患有严重冠心病的受试者为与载脂蛋白A-I探针杂交的6.5kb片段的纯合子。在动脉粥样硬化患者组中，44%的人是该片段的杂合子，而对照组中这一比例为9.5%。动脉粥样硬化组和对照组的基因型分布存在显著差异。在杂合子受试者中，用Bam HI限制性内切酶消化其DNA后发现了特定差异。
