Thompson D W
J Assoc Off Anal Chem. 1986 Sep-Oct;69(5):811-3.
Capillary gas chromatography is evaluated for multicomponent drug analysis. A 0.32 mm id X 30 m fused silica column and a 0.75 mm id X 30 m borosilicate glass column (both with OV-1 bonded phase) are investigated. Retention times (relative to caffeine) are presented for 39 drug components representing a variety of chemical classes and pharmacological activities. Reproducibility data are presented for both isothermal and programmed temperature runs on selected drug mixtures. Recovery data are provided for 2 multicomponent drug mixtures prepared to approximate over-the-counter antihistaminic and antitussive preparations.
对毛细管气相色谱法进行多组分药物分析评估。研究了一根内径0.32毫米×30米的熔融石英柱和一根内径0.75毫米×30米的硼硅酸盐玻璃柱（两者均带有OV - 1键合相）。给出了代表多种化学类别和药理活性的39种药物成分的保留时间（相对于咖啡因）。给出了在选定药物混合物上进行等温及程序升温运行的重现性数据。提供了两种模拟非处方抗组胺药和止咳药制剂制备的多组分药物混合物的回收率数据。
